Sex effect on cortical neurodegeneration in isolated REM sleep behavior disorder and its association with clinical manifestations
Isolated rapid-eye movement (REM) sleep behavior disorder (iRBD), a condition where people act out their dreams, is a major early indicator of Parkinson’s disease and related disorders. This project will analyze brain scans from hundreds of iRBD patients to determine whether patterns of brain atrophy differ between men and women. Researchers will also examine how these sex-specific changes relate to symptoms and underlying gene expression. The goal is to uncover biological differences that could improve early detection and guide more personalized approaches to preventing neurodegenerative disease.
