Amyotrophic Lateral Sclerosis (ALS) is a fatal disease that damages nerve cells controlling movement, and many patients also experience major changes in how their bodies use energy. Early research suggests that a ketogenic diet, which is high in fats and low in carbohydrates, may help by improving how mitochondria, the cell’s energy producers, function. This project will study how this diet affects metabolism, mitochondrial health, and brain networks in a mouse model of ALS with a FUS gene mutation. The goal is to uncover new treatment strategies that use these metabolic benefits to improve life for people with ALS.
